Technology may have changed many aspects of our lives, but as the opening scenes of Mistress America show, the fish-out-of-water feeling young adults get when they start university/college is not one of them. Being new and away from home is still hard, and Tracy (Lola Kirke) is having a tough time fitting in. She isn’t a social butterfly, and she apparently doesn’t make the grade to join her university’s coveted literary society. Feeling lonely, she makes contact with Brooke (Greta Gerwig), her 30ish-year-old, soon-to-be step sister who lives in New York City. The two form an unlikely friendship, and Brooke’s unconventional lifestyle becomes a source of inspiration (both personally and creatively) for Tracy.